COVID vaccines still protect against heart problems, large study finds
Fuente: Ars Technica
A major new study has found that updated COVID-19 vaccines continue to provide meaningful protection against serious cardiovascular events, even as the virus has evolved and population immunity has grown. Published in JAMA Internal Medicine, the research drew on data from over one million patients in the US Department of Veterans Affairs health system, making it one of the largest analyses of its kind to examine the heart-related benefits of the most recent COVID-19 shots.
The study compared patients who received both the 2024–2025 COVID-19 vaccine and a seasonal flu shot against those who received only the flu shot, which served as the control group. Researchers tracked major adverse cardiovascular events, known as MACE, over eight months. These events included cardiovascular death, heart attack, stroke, and hospitalization for heart failure. The overall vaccine effectiveness against COVID-19-associated MACE was found to be 38 percent.
In absolute terms, the protective benefit is modest but clinically meaningful. The COVID-19 vaccine reduced the rate of associated MACE events from approximately 5 in 10,000 patients to 3 in 10,000. The benefits were most pronounced among people aged 75 and older and those with pre-existing medical conditions. This suggests the vaccine continues to deliver its strongest protection to those who are most medically vulnerable and at greatest risk of severe outcomes.
The researchers, led by epidemiologist Ziyad Al-Aly, also examined MACE and deaths in cases where COVID-19 infection had not been formally documented. The protective effect appeared even greater in this group, suggesting that many COVID-19 infections went undetected. Extrapolating their findings to a hypothetical population of one million people, the team estimated that vaccination could plausibly prevent around 2,370 MACE events and 1,580 deaths over an eight-month period.
The study does carry notable limitations. The VA patient population is predominantly older, White, and male, which means the findings may not fully generalize to the broader US population. Nevertheless, the results reinforce the case that COVID-19 vaccines continue to offer meaningful cardiovascular protection, a benefit that scientists say should inform individual decisions about whether to receive the updated seasonal shots, particularly for high-risk groups.
Traducción al japonés
新たな大規模研究により、新型コロナウイルスのワクチンが更新されたにもかかわらず、深刻な心血管疾患に対する有意な保護効果が継続していることが明らかになった。米退役軍人省の医療システムに登録された100万人以上の患者データを基に実施されたこの研究は、JAMA Internal Medicine誌に掲載され、最新のコロナワクチンの心臓保護効果を検証した最大規模の分析の一つとなっている。
研究では、2024〜2025年版の新型コロナワクチンとインフルエンザワクチンの両方を接種した患者と、インフルエンザワクチンのみを接種した対照群とを比較した。研究チームは8か月間にわたり、心血管死、心筋梗塞、脳卒中、心不全による入院などを含む重大な心血管有害事象(MACE)を追跡。コロナワクチンのMACEに対する全体的な予防効果は38%であった。
絶対数でみると効果は控えめだが、臨床的には意義がある。コロナワクチンにより、関連するMACEの発生率は1万人当たり約5件から3件に低下した。特に75歳以上の高齢者や基礎疾患を持つ患者においてその効果が顕著であり、医療的に最も脆弱で重症化リスクの高い層において、ワクチンが最大の保護効果を発揮し続けていることを示している。
疫学者ザイヤド・アル=アリー氏が率いる研究チームは、コロナ感染が正式に記録されていない症例におけるMACEや死亡についても分析した。このグループでは保護効果がさらに強く現れており、多くの感染が見逃されていた可能性が示唆された。仮に100万人の集団に当てはめると、ワクチン接種により8か月間でMACEを約2,370件、死亡を約1,580件防げると推計されている。
この研究にはいくつかの限界もある。退役軍人省の患者は高齢の白人男性が多数を占めており、結果が米国全体の人口に当てはまらない可能性がある。それでも、コロナワクチンが心血管に対する有意な保護効果を引き続き示しているという知見は、特にリスクの高い集団が最新の季節性ワクチンを接種するかどうかを判断する際の重要な根拠となると、研究者たちは述べている。
Vocabulario clave
- eschewverb
To deliberately avoid or abstain from something, typically on moral or practical grounds.
和訳: 避ける、遠ざける
Many people have eschewed processed foods in favor of a more natural diet.
- hold upidiom
To remain valid, effective, or strong over time or under pressure.
和訳: 持ちこたえる、有効であり続ける
The theory held up well even after years of rigorous scientific scrutiny.
- adverseadjective
Harmful, unfavorable, or working against someone or something; often used in medical or formal contexts.
和訳: 有害な、不利な
Patients were monitored closely for any adverse reactions to the new treatment.
- extrapolateverb
To extend or project known data or findings to estimate or infer unknown situations or larger populations.
和訳: 外挿する、推定する
Scientists extrapolated from the trial results to predict the drug's nationwide impact.














